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Evidence for Early Membrane Antigens in Cytomegalovirus-infected Cells

¹ Department of Virology, Cancer Research Institute Kanazawa University, Kanazawa 920, Japan
² Department of Obstetrics and Gynecology Ishikawa Prefectural Central Hospital, Kanazawa 920-02, Japan

Human cytomegalovirus (HCMV) induces membrane antigens (MA) which are detectable by immunofluorescent techniques as early as 24 h after infection. These antigens appear on the surface of infected cells in non-permissive human epithelioid and animal cells in addition to permissive human cells. The synthesis of the MA occurs in the presence of a DNA synthesis inhibitor, whereas RNA and protein synthesis inhibitors prevent its formation completely. These results demonstrate that the MA is a newly synthesized protein coded by an early function of the viral genome.

Received 19 July 1980; accepted 6 October 1980.