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Cellular Source of Interferon Induced in Human Peripheral Blood Mononuclear Leukocytes by Mumps Virus or by Tumour Cells Persistently Infected with Mumps Virus

Department of Microbiology, Hokkaido University School of Medicine, Sapporo 060, Japan

Human leukocyte interferon (IFN-) was induced in cultures of human peripheral blood mononuclear leukocytes (PBML) from seropositive healthy donors infected by mumps virus, or by a human lung carcinoma cell line (Pc-10) persistently infected with mumps virus (Pc-10/MpV). Adherent cells (M), non-T, non-B cells and B cells all produced IFN in response to mumps virus or Pc-10/MpV cells. The non-T, non-B cells co-cultured with Pc-10/MpV cells produced high-titred IFN. However, T cells did not produce any antiviral factors even in the presence of M. Furthermore, T cells activated with phytohaemagglutinin (PHA-P), concanavalin A or treated with u.v.-irradiated mumps virus, or Pc-10/MpV cells pretreated with mitomycin C did not produce any antiviral factors in response to either mumps virus or Pc-10/MpV cells.

Received 26 November 1980; accepted 26 January 1981.

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