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The Relationship between Genomic RNAs of Polycythaemic Forms of Spleen Focus-forming Friend Virus and its Helper Virus

J. N. M. Mol^1,

¹ Institute of Pathology, Faculty of Medicine, Erasmus University, P.O. Box 1738, Rotterdam, The Netherlands
The² Beatson Institute for Cancer Research, Wolfson Laboratory for Molecular Pathology, Garscube Estate, Bearsden, Glasgow G61 1BD, U.K.

We have studied the relationship between Friend spleen focus-forming virus (SFFV) and its helper lymphoid leukaemia virus (LLV) by comparing RNase T1 fingerprints of genomic RNAs. Our data indicate that about 70% of the SFFV sequence is a perfect copy of parts of the helper genome. We conclude that our SFFV and LLV isolates have co-evolved very closely and that SFFV-specific sequences are not identical in different Friend virus isolates.

Present address: Department of Genetics, Free University, De Boelelaan 1087, 1007MC Amsterdam, The Netherlands.

Received 27 October 1980; accepted 26 January 1981.