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1 Department of Enteroviruses National Institute of Health, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan
2 Department of Viral Infection Institute of Medical Science University of Tokyo, Tokyo 108, Japan
Human papovavirus BK DNA resistant to digestion with EcoRI endonuclease had the capacity to direct synthesis of T antigen in human embryonic kidney cells. The study demonstrated the natural occurrence of defective deletion mutants with intact early functions of the viral genome.
Received 8 December 1980;
accepted 2 February 1981.
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