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J Gen Virol 54 (1981), 431-435; DOI 10.1099/0022-1317-54-2-431
© 1981 Society for General Microbiology

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Natural Occurrence of Deletion Mutant of Human Papovavirus BK Capable of Inducing T Antigen

Sumie Watanabe1 and Kunito Yoshiike1

1 Department of Enteroviruses National Institute of Health, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan

Yasuhito Yuasa2 and Seijiro Uchida2

2 Department of Viral Infection Institute of Medical Science University of Tokyo, Tokyo 108, Japan

Human papovavirus BK DNA resistant to digestion with EcoRI endonuclease had the capacity to direct synthesis of T antigen in human embryonic kidney cells. The study demonstrated the natural occurrence of defective deletion mutants with intact early functions of the viral genome.

Received 8 December 1980; accepted 2 February 1981.





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