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J Gen Virol 54 (1981), 437-442; DOI 10.1099/0022-1317-54-2-437
© 1981 Society for General Microbiology
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A Hybridoma Cell Line Secreting Antibody to Poliovirus Type 3 D-Antigen: Detection in Virus Harvest of Two D-Antigen Populations

Morag Ferguson, G. C. Schild, P. D. Minor, P. J. Yates and M. Spitz

Division of Viral Products and Immunology Section National Institute for Biological Standards and Control, Holly Hill, Hampstead, London NW3 6RB, U.K.

A mouse hybridoma cell line (Mo56) secreting IgG antibody to poliovirus type 3 D-antigen was obtained by fusion of a mouse myeloma cell line with spleen cells from mice immunized with Saukett virus. The monoclonal antibody was specific for Saukett virus strains in virus-neutralization and single-radial-diffusion tests. In immunoprecipitation tests the monoclonal antibody reacted with intact infectious virus particles (155S) and with a previously undescribed 70S poliovirus particle with D-antigenic reactivity.

Received 6 November 1980; accepted 10 February 1981.




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Copyright © 1981 by the Society for General Microbiology.