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Modification and Exploitation of a Poliovirus-induced Membrane Complex by Superinfecting ME Virus

Institut für Klinische und Experimentelle Virologie, Freie Universität Berlin, Hindenburgdamm 27, D-1000 Berlin 45, West Germany

The replication of Mouse Elberfeld (ME) virus was accelerated when HEp-2 cells were mixedly infected with poliovirus in the presence of guanidine. The latent period of the replication of ME virus was shortened by 3 h when cells were preinfected for at least 2 h with poliovirus and inhibited by guanidine. Simultaneous infection with poliovirus and ME virus resulted in a shortening by 1 h of the latent period of ME virus replication. The accelerated replication of ME virus was shown to be due to modification and exploitation of a membrane complex induced by poliovirus in the presence of guanidine; on superinfection ME virus successively modified this poliovirus-induced complex of 470S (‘light’ complex) into a ‘heavy’ complex of 700S specific for ME virus.

Keywords: picornaviruses, superinfection, reproduction, membrane modification

Received 29 August 1980; accepted 24 March 1981.