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Suppressive Effects of Interferon on Cell Fusion by Sendai Virus

Department of Microbiology, School of Medicine, Chiba University, Chiba 280, Japan

Suppressive effects of human IFN-, IFN- and mouse-IFN on syncytium formation in human and mouse transformed cells have been studied using u.v.-irradiated Sendai virus (UV-Sendai virus). After treatment of human RSa cells with 500 units/ml human IFN- for 16 h, the syncytium formation induced by UV-Sendai virus was reduced to less than 10% of controls. The suppressive effect was dependent on the amount of interferon added, and it was blocked by the addition of cycloheximide. Suppression of syncytium formation was also observed on human IF^r cells, which are partially resistant to the anticellular effect of interferon but are sensitive to the antiviral effect of interferon. Human IFN- also had a suppressive effect on syncytium formation in human transformed cells, and human IFN-, IFN- and mouse IFN showed species specificity in their effect on fusion. This anti-cell fusion activity was developed in IF^r cells from about 5 h after addition of IFN- and when the cells were treated with IFN- for 16 h, the resistant state of cells continued for over 20 h after removal of IFN-.

Keywords: interferon, cell fusion, syncytium, Sendai virus

Received 5 January 1981; accepted 25 March 1981.

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