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An Interference Phenomenon Associated with a Measles Virus SSPE Isolate (Halle)

Neurovirology Research Unit Department of Medical Microbiology Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2H7

A measles virus (Halle SSPE isolate) induced ring plaque phenomenon (concentric rings of living and dead cells) has been shown to be associated with the temperature-dependent production of interfering particles. The interfering particles have been purified by potassium tartrate linear gradient centrifugation and have buoyant densities of 1.15 g/ml (M particle) and 1.06 g/ml (L particle) respectively. Both interfering particle populations have been shown to decrease the yield of wild-type measles virus from infected cells by 50% when co-infection experiments were performed. Neither the M or L particle population interfered with the growth of VSV in the same host-cell system.

Keywords: measles virus, interference, plaques, SSPE isolate

Received 6 February 1981; accepted 27 May 1981.