HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Blackwell, J. H. Articles by Kosikowski, F. V. Search for Related Content PubMed PubMed Citation Articles by Blackwell, J. H. Articles by Kosikowski, F. V. Agricola Articles by Blackwell, J. H. Articles by Kosikowski, F. V.

Vesicular Exocytosis of Foot-and-Mouth Disease Virus from Mammary Gland Secretory Epithelium of Infected Cows

Plum Island Animal Disease Center Agricultural Research, Science and Education Administration, U.S. Department of Agriculture, Greenport, New York 11944
¹ Department of Food Science Cornell University, Ithaca, New York 14853, U.S.A.

Foot-and-mouth disease virus particles were observed by electron microscopy in the cytoplasm of alveolar secretory cells of the bovine mammary gland after contact exposure of uninfected cows to pigs with foot-and-mouth disease. Virus, contained in membrane-limited vesicles, was released from the basal and peranuclear portions of the cell into the intracellular and extracellular spaces by an exocytotic mechanism similar to that of the release of the milk-fat globule. Virus was released into the lumen from the apical portion of the cell both by membrane-limited vesicles and by the merocrinal exocytosis of casein-associated virus. The lytic release of virus was observed in 20% of the preparations observed.

Keywords: FMD virus, secretory epithelium, casein micelle

Received 4 November 1980; accepted 31 March 1981.

This article has been cited by other articles:

				P. M. Tomasula, M. F. Kozempel, R. P. Konstance, D. Gregg, S. Boettcher, B. Baxt, and L. L. Rodriguez Thermal Inactivation of Foot-and-Mouth Disease Virus in Milk Using High-Temperature, Short-Time Pasteurization J Dairy Sci, July 1, 2007; 90(7): 3202 - 3211. [Abstract] [Full Text] [PDF]

				P. M. Tomasula and R. P. Konstance The Survival of Foot-and-Mouth Disease Virus in Raw and Pasteurized Milk and Milk Products J Dairy Sci, April 1, 2004; 87(4): 1115 - 1121. [Abstract] [Full Text] [PDF]