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J Gen Virol 57 (1981), 227-231; DOI 10.1099/0022-1317-57-1-227
© 1981 Society for General Microbiology
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Mechanisms of Early and Late Polykaryocytosis Induced by the Bovine Leukaemia Virus

B. Guillemain, R. Mamoun, T. Astier and J. F. Duplan

Institut National de la Santé et de la Recherche Médicale Unité 117, 229, cours de l'Argonne 33076 Bordeaux, France

Syncytia formation induced by the bovine leukaemia virus (BLV) has been classified as ‘early’ or ‘late’ polykaryocytosis. Early polykaryocytosis arises in the first 24 h in mixed cultures of BLV-infected cells with indicator cells. Late polykaryocytosis is observed 4 to 8 days after infection of sensitive cells with cell-free infectious BLV. Our results demonstrate that the two phenomena proceed from different mechanisms. Late polykaryocytosis results from an active process dependent on the integrity of the virus genome. In contrast, early polykaryocytosis is a passive process which does not require any de novo virus synthesis but is dependent on the presence of virus proteins in inducer cells.

Keywords: bovine leukaemia virus, early polykaryocytosis, late polykaryocytosis

Received 25 February 1981; accepted 15 July 1981.


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A. Shimizu, N. Shimizu, A. Tanaka, A. Jinno-Oue, B. B. Roy, M. Shinagawa, O. Ishikawa, and H. Hoshino
Human T-cell leukaemia virus type I is highly sensitive to UV-C light
J. Gen. Virol., August 1, 2004; 85(8): 2397 - 2406.
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