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Detection of Hepatitis B Virus-specific DNA in the Genomes of Human Hepatocellular Carcinoma and Liver Cirrhosis Tissues

¹ Max-Planck-Institut für Biochemie, 8033 Martinsried bei München, Federal Republic of Germany
² Institut de Virologie, Tours, France
³ MHH, Dept. für Innere Medizin, 3000 Hannover 61, Federal Republic of Germany

Hepatitis B virus-related DNA was detected in the chromosomal DNA of three out of seven hepatocellular carcinomas and two out of five cirrhosis samples examined, by means of the blot-hybridization technique, described by Southern (1975). The integration patterns were not identical but some similarities raise the question of whether there are some preferred sites of viral integration.

Keywords: HBV DNA, integrated genomes, hepatocellular carcinomas, cirrhosis

Received 15 June 1981; accepted 22 July 1981.

This article has been cited by other articles:

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