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2'–5' Oligo(A) Synthetase Levels in Interferon-sensitive or -resistant Lymphoid Cells

Department of Cell Biology and Virology Theagenion Medical Institute, Thessaloniki, Greece

The activity of 2'–5' oligo(A) synthetase has been measured both in control and interferon-treated lymphoid cells. While control or interferon-treated Raji and Namalwa cells exhibit low activity of the 2'–5' oligo(A) synthetase, the activity of this enzyme is increased 20-fold when Daudi cells are treated with the same dose of human interferon. The same enzyme is induced by interferon in R3HR-1 cells to a lesser extent.

Keywords: interferon, 2'–5' oligo(A) synthetase

Received 25 June 1981; accepted 15 September 1981.