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J Gen Virol 58 (1982), 37-46; DOI 10.1099/0022-1317-58-1-37
© 1982 Society for General Microbiology
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Monoclonal Antibodies to Sindbis Virus Glycoprotein E1 can Neutralize, Enhance Infectivity, and Independently Inhibit Haemagglutination or Haemolysis

A. C. Chanas, E. A. Gould, J. C. S. Clegg1 and M. G. R. Varma

Arbovirus Research Unit, London School of Hygiene and Tropical Medicine, Winches Farm Field Research Station, St. Albans, Herts, U.K.
and1 Special Pathogens Reference Laboratory, PHLS Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wilts, U.K.

Two monoclonal antibodies raised against Sindbis virus were shown to be specific for the envelope glycoprotein E1 by radioimmunoprecipitation (RIP). They had a number of contrasting biological properties. One of them was capable of neutralizing virus infectivity and inhibiting haemagglutination, while the other had no significant neutralizing or haemagglutination-inhibiting capability, but did inhibit virus-mediated haemolysis. Both monoclonal antibodies could enhance virus infectivity of Fc receptor-bearing macrophage-like cells when present at suitable dilutions.

Keywords: Sindbis, monoclonal, haemolysis, enhancement

Received 30 June 1981; accepted 28 August 1981.


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