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The Effect of Hypertonic Salt on Interferon and Interferon mRNA Synthesis in Human MG63 Cells

¹ Division of Viral Products The National Institute for Biological Standards and Control, Holly Hill Hampstead, London NW3 6RB, U.K.
² Department of Biological Sciences University of Warwick, Coventry CV4 7AL, U.K.

After infection with Sendai virus or Newcastle disease virus (NDV) strain F, human osteosarcoma MG63 cells produced large amounts of interferon-. Both interferon production and overall protein synthesis were strongly inhibited by hypertonic salt. Interferon mRNA synthesis, however, was little affected by hypertonic salt up to twice normal salt concentrations, although cellular RNA synthesis was inhibited under these conditions. The results are compared to those obtained with polyriboinosinic acid:polyribocytidylic acid copolymer [poly(rI).poly(rC)] inductions of MG63 cells.

Keywords: hypertonicity, interferon, mRNA, human

Received 25 August 1981; accepted 2 November 1981.