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Role of Viral Glycoproteins in Haemolysis by Influenza B Virus

¹ Department of Microbiology Germ-free Life Research Institute
and² Department of Paediatrics Nagoya University School of Medicine, Nagoya, Japan

Influenza B virus exhibited haemolytic activity at low pH, but the pH profile for its activity varied from strain to strain. The results of selective heat-inactivation of the enzyme activity of neuraminidase (NA) or elimination from virions of the enzyme-active portion of the NA molecule by trypsin digestion, suggest that proteolytically cleaved haemagglutinin, but not enzyme activity of NA, is essential for haemolysis by influenza B virus.

Keywords: influenza B, haemolysis, low pH, neuraminidase activity

Received 4 September 1981; accepted 9 November 1981.