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J Gen Virol 59 (1982), 193-196; DOI 10.1099/0022-1317-59-1-193
© 1982 Society for General Microbiology
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Inhibition of La Crosse Virus Replication by Monensin, a Monovalent Ionophore

Phillip Cash

Department of Bacteriology University of Aberdeen, Foresterhill, Aberdeen AB9 2ZD, U.K.

The effect of monensin, a monovalent ionophore, on La Crosse virus particle formation and polypeptide synthesis was examined. Monensin inhibited the release of virus particles (both infectious and non-infectious) from infected BHK-21 cells. Monensin had no detectable effect on the synthesis of polypeptides G1, G2 and N.

Keywords: La Crosse virus, replication, monensin

Received 14 July 1981; accepted 20 October 1981.




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