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Transplacental Japanese Encephalitis Virus (JEV) Infection in Mice During Consecutive Pregnancies

Asha Mathur

Virus Laboratory Department of Pathology and Bacteriology K. G. Medical College, Lucknow-3, India

Transplacental transmission of Japanese encephalitis virus (JEV) has been demonstrated in consecutive pregnancies of mice. Pregnant mice inoculated intraperitoneally with JEV transmit the virus to the foetus. When such female mice were mated again after 6 months, the virus could be isolated from the foetuses of the ensuing pregnancy. The incidence of abortion was increased significantly though the neonatal deaths were considerably less than during the first pregnancy. Intra-uterine infection occurred in spite of the presence of HAI antibodies against JEV in the preconceptional sera of the mice. The findings of the present study indicate the value of such a system for further investigations of the pathogenesis of JEV infection during pregnancy in humans.

Keywords: JEV, transplacental infection, virus persistence

Mailing address: C 11/7, River Bank Colony, Lucknow-226 001, India.

Received 11 June 1981; accepted 19 October 1981.