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The Presence of -Interferon in Human Amniotic Fluid

¹ Institut Nationale de la Santé et de la Recherche Médicale, U.43
and² Laboratoire de Cytogénétique Hôpital Saint Vincent-de-Paul 74, avenue Denfert-Rochereau, 75014 Paris, France

Almost all the samples of amniotic fluid from 62 pregnant women from the 16th week to the end of the pregnancy contained detectable amounts of -type interferon. The presence of this substance in amniotic fluid during pregnancy raises the question of the physiological significance of this finding. It is postulated that the amniotic type of -interferon might be a product of a constitutive gene, rather than induced by latent virus infection.

Keywords: amniotic fluid, IFN-, immune tolerance, foetal development

Received 14 September 1981; accepted 11 November 1981.