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Interferon Production by Myxoviruses in Chick Embryo Cells

Department of Biochemistry, Marischal College, University of Aberdeen, Scotland

Both fowl plague and Newcastle disease viruses failed to produce interferon in chick-embryo cells because of the inhibitory effect of infection on host-cell protein synthesis. When this inhibitory effect was destroyed by ultraviolet irradiation or by hydroxylamine inactivation, interferon was formed. No virus RNA synthesis could be detected in the interferon-producing cells and it was concluded that the virus single-stranded RNA was the stimulus for interferon formation.

^* Present address: Division of Biological Sciences, University of Warwick, Coventry, Warwickshire.

Received 7 July 1969; accepted 27 August 1969.