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Mise en Evidence de Certaines Activités Déshydrogénasiques dans des Fibroblastes Aviaires Transformés in vitro par le Virus du Sarcome de Rous

Laboratoire de Médecine Expérimentale, Collège de France, Paris, France

The present work reports on the sites of lactic-, isocitric-, succinic-, malic- and glucose-6-phosphatic dehydrogenases in chick embryo fibroblast cultures infected with Rous sarcoma virus (SCHMIDT-RUPPIN strain) using cytochemical methods.

It was found that in RSV transformed cells reactive sites are both more numerous and appear more heavily stained than uninfected, dividing fibroblasts or fibroblasts infected with two other viruses of the avian leukosis group (RAV 1–2).

These results seem to indicate that, in the case of Rous sarcoma virus infection of the chicken and under these experimental conditions, the glycolysis of the transformed (neoplastic) cells is not accompanied by a decrease of the respiratory enzymes studied here.

Received 14 October 1968; accepted 25 July 1969.