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Target Molecular Weight of Foot-and-Mouth Disease Virus and Poliovirus

Departamento de Virologia Facultad de Medicina Departamento de Biologia Facultad de Ciencias Universidad de Chile

The use of ionizing radiation has given much information on the size and structure of virus particles (Ginoza, 1963; Contreras & Ohlbaum, 1968). The relation between virus particle size and sensitivity to inactivation by ionizing radiation was postulated by Lea (1940); later, the target theory was developed (Lea, 1946; Timofeeff-Ressovsky & Zimmer, 1947). The amount of genetic material in a virus can be determined by calculating the target molecular weight (Ginoza, 1967). Even though it is generally accepted that the RNA of picornaviruses has a molecular weight of about 2 x 10⁶ (Allison & Burke, 1962), there is very little information about the molecular weight of the genome of many of them. The present study was undertaken to determine the size of the genome of foot-and-mouth disease virus by means of -irradiation. For the purpose of comparison, we irradiated simultaneously another enterovirus, poliovirus, under identical experimental conditions.

Received 15 July 1969; accepted 8 October 1969.