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Echovirus 11 Dense Particles: Isolation and Preliminary Characterization

Laboratoire National de la Santé Departement D'Etude des Maladies Virales, 8 avenue Rockefeller, 6973 Lyon Cedex 2, France

Dense particles (density 1.44 g/ml) were isolated during purification in CsCl of echovirus 11 produced in HeLa cells. The dense particles had similar antigenic properties and similar RNA and protein composition to standard (density 1.33 g/ml) echovirus 11 particles. They differed from standard particles in their higher buoyant density, lower infectivity and slightly smaller diameter. In contrast to other picornavirus dense particles, echovirus 11 dense particles were present as a major component of virus population. This high ratio of dense particles was found only in virus from HeLa cells which produced non-haemagglutinating echovirus 11. Haemagglutinating echovirus 11 from primary monkey kidney (MK) cells did not contain any detectable levels of dense particles.

Keywords: dense particles, echovirus 11, buoyant density, picornavirus

Received 8 July 1981; accepted 15 December 1981.