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Immune Stimulation of Sensitized Chicken Lymphocytes by Avian Retrovirus Proteins

Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis Jewish General Hospital, 3755 Cote Sainte Catherine Road, Montreal Quebec, Canada H3T 1E2 Department of Microbiology and Immunology McGill University, Montreal, Quebec, Canada

Peripheral blood lymphocytes of chickens bearing tumours induced by avian sarcoma virus can be specifically stimulated to divide by the crude culture fluids of virus-infected cells. In this communication, we show that relevant antigenic activity apparently resides in each of the internal virus proteins p15 and p27. The ability of infectious culture fluids to be mitogenic for sensitized lymphocytes is greatly reduced following treatment with antibodies specific for either total avian myeloblastosis virus (AMV) protein or for p27.

Keywords: avian retrovirus, lymphocyte, immune stimulation, proteins

Received 31 July 1981; accepted 28 January 1982.