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J Gen Virol 60 (1982), 397-400; DOI 10.1099/0022-1317-60-2-397
© 1982 Society for General Microbiology
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The Role of Liver in the Catabolism of Human {alpha}- and beta-Interferon

V. Bocci, A. Pacini, L. Bandinelli1, G. P. Pessina, M. Muscettola and L. Paulesu

Istituto di Fisiologia Generale Università, 53100 Siena, Italy
1 Istituto Sieroterapico ‘A. Sclavo’, Siena, Italy

The susceptibility of human leukocyte ({alpha}), fibroblast (beta) and recombinant {alpha}-2-interferons to clearance by the isolated and perfused rabbit liver has been evaluated. Human leukocyte and recombinant {alpha}-2-interferons were stable and their initial levels were maintained in the perfusate even if they had been treated with neuraminidase, thus suggesting that {alpha}-interferons have no exposed sugars recognizable by hepatic binding proteins. On the other hand, native, and particularly desialylated human beta-interferon, underwent marked hepatic uptake confirming the importance of the liver as a catabolic site for glycosylated interferons.

Keywords: interferons, asialointerferons, liver catabolism, hepatic binding protein

Received 10 November 1981; accepted 5 February 1982.


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