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J Gen Virol 61 (1982), 111-114; DOI 10.1099/0022-1317-61-1-111
© 1982 Society for General Microbiology
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Failure of Guanidine and 2-({alpha}-Hydroxybenzyl)benzimidazole to Inhibit Replication of Hepatitis A Virus In vitro

G. Siegl1

1 Institut für Hygiene und Medizinische Mikrobiologie Universität Bern, Friedbühlstrasse 51, CH-3010 Bern, Switzerland

H. J. Eggers2

2 Institut für Virologie der Universität zu Köln, Fürst-Pückler-Strasse 56, D-5000 Köln 41, Federal Republic of Germany

Replication of hepatitis A virus (HAV) in the human hepatoma-derived PLC/PRF/5 cell line was neither inhibited in the presence of various concentrations of guanidine or D-2-({alpha}-hydroxybenzyl)benzimidazole (D-HBB), nor were the two chemicals effective in combination. Under identical conditions, however, replication of poliovirus type 1 was inhibited. Tracer experiments with radiolabelled guanidine and D-HBB also furnished no evidence that the two antiviral substances were metabolized gradually to inactive derivatives in PLC/PRF/5 cells. Therefore, it is concluded that resistance to the action of guanidine and D-HBB is an inherent characteristic of HAV. However, the insensitivity of HAV to these drugs does not exclude the virus from the family of picornaviruses.

Keywords: HAV, replication inhibitors, classification, antiviral substances

Received 22 December 1981; accepted 25 February 1982.


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M. Yi and S. M. Lemon
Replication of Subgenomic Hepatitis A Virus RNAs Expressing Firefly Luciferase Is Enhanced by Mutations Associated with Adaptation of Virus to Growth in Cultured Cells
J. Virol., February 1, 2002; 76(3): 1171 - 1180.
[Abstract] [Full Text] [PDF]


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