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Central Laboratory of The Netherlands Red Cross Blood Transfusion Service and Laboratory of Clinical and Experimental Immunology of the University of Amsterdam, Amsterdam, The Netherlands
Adult athymic Nu/Nu mice showed increased susceptibility to lethal infection with murine cytomegalovirus (MCMV) when compared to their heterozygous T cell-competent Nu/+ littermates. However, the extent of this increase in susceptibility varied dramatically depending on the genetic background of the mice carrying the Nu/Nu gene. Genetically susceptible Balb/c (H-2d) mice showed a greater than 316-fold difference between the LD50 of Nu/Nu and Nu/+ littermates. In marked contrast, the genetically resistant CBA (H-2k) strain was characterized by only a 16-fold difference in resistance between Nu/Nu and Nu/+ mice, and furthermore, the athymic CBA Nu/Nu mice were no more susceptible than the T cell-competent Balb/c Nu/+ strain. These results together with previous observations strongly suggest that the (H-2k)-associated resistance of the CBA strain is mediated by non-T cell-dependent early defence mechanisms.
Keywords: MCMV, genetic resistance, nude mice, genetic control
Present address: Department of Microbiology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, 6009, Western Australia.
Received 18 August 1981;
accepted 22 February 1982.
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