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Molecular Basis of Rabies Virus Virulence. I. Selection of Avirulent Mutants of the CVS Strain with Anti-G Monoclonal Antibodies

¹ Bât. 400, Université Paris-Sud, 91405 Orsay Cedex, France
² Institut Pasteur, Centre Antirabique, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
³ Centre National d'Etudes sur la Rage, BP 9, 54220 Malzeville, France

Two avirulent mutants of the CVS strain of rabies virus were isolated from clones resistant to one neutralizing monoclonal antibody. The virulence of clones resistant to three other anti-glycoprotein monoclonal antibodies was similar to that of the wild-type.

Keywords: avirulent mutant, rabies virus, monoclonal antibodies

Received 29 January 1982; accepted 3 March 1982.

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