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Neuronal Function Impairment in Rabies-infected Rat Brain

Unité Rage, Département de Virologie Institut Pasteur, 28, rue du Dr Roux 75724, Paris Cedex 15, France

In homogenates of rabies-infected rat brain the specific binding of a tritium-labelled antagonist of muscarinic acetylcholine (mACh) to mACh receptors (mAChR) varied during the course of infection. A small increase in the binding of the antagonist, quinuclidinyl benzylate (QNB), during the first days after infection was followed by a marked decrease as the symptoms of rabies appeared. Measurements of ³H-labelled QNB binding in dissected brain regions, i.e. brain stem, caudatus nucleus, cortex, hippocampus, cerebellum and medulla, showed that the decrease in binding was greater in the hippocampus than in any other brain region. We conclude that in the central nervous system (CNS) of the rabies-infected rat neuronal impairment may be one manifestation of rabies pathogenesis.

Keywords: rabies, muscarinic acetylcholine receptor, CNS, rats

Received 28 August 1981; accepted 11 March 1982.