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The 3' Terminal RNA Sequences of Bunyaviruses and Nairoviruses (Bunyaviridae): Evidence of End Sequence Generic Differences within the Virus Family

Corrie M. Clerx-van Haaster

John P. M. Clerx

Department of Microbiology The Medical Center University of Alabama in Birmingham, Birmingham, Alabama 35294, U.S.A.

The 3' terminal nucleotide sequences of the three virus RNA species of viruses representing eight serogroups of bunyaviruses (genus Bunyavirus, Bunyaviridae) and six serogroups of nairoviruses (genus Nairovirus, Bunyaviridae) have been characterized. Members of the Bunyavirus genus have conserved 3' end sequences (generally, 3' UCAUCACAUGA...) that differ from the conserved 3' end sequences of members of the Nairovirus genus (generally, 3' AGAGUUUCU...).

Keywords: bunyavirus, nairovirus, 3' terminal nucleotide sequences

Present address: Institut fur Medizinische Mikrobiologie der Technischen, Universitat Munchen, Virologische Abteilung, 8000 Munchen 40, F.R.G.

Received 18 March 1982; accepted 20 April 1982.

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