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Canine Parvovirus: a Biochemical and Ultrastructural Characterization

Institute for Medical Research of Bennington, 110 Hospital Drive, Bennington, Vermont 05201, U.S.A.

A canine virus derived from a diseased dog has been plaque-purified and characterized in detail. Analysis of infected cells demonstrated that virus antigen accumulated in the nucleus at 12 to 24 h post-infection and the cytopathology at the ultrastructural level was diagnostic of a parvovirus infection. The purified virus particles were 23 to 26 nm in diam. and banded at a density 1.44 g/ml in CsCl. Detailed biochemical analysis revealed a single-stranded DNA genome and three structural proteins of mol. wt. 82300, 67300 and 63500. All of the data presented are consistent with the classification of this virus as a parvovirus.

Keywords: canine parvovirus, biochemistry, ultrastructure

Received 10 November 1981; accepted 26 March 1982.

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