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Identification of the Cap-binding Protein of Two Strains of Influenza A/FPV

¹ Division of Virology, Department of Pathology University of Cambridge, Laboratories Block Addenbrooke's Hospital, Hills Road, Cambridge, U.K.
² Institute of Biochemistry, University of Vienna, A-1090 Vienna, 9 Währingerstrasse 17, Austria

We have identified the cap-recognizing protein of two strains of influenza A fowl plague virus (FPV) by photoaffinity labelling of virion proteins with a photoreactive analogue of the 5'-methyl cap structure of messenger RNA. The cap-recognizing protein of influenza A/FPV/Rostock/34 is the P2 polypeptide, and that of influenza A/FPV/Dutch/27 (Dobson) is the P3 polypeptide. In each case the cap-recognizing protein is the product of RNA segment 1.

Keywords: influenza A(FPV), 5'-cap recognition, cap-binding protein

Received 22 March 1982; accepted 10 May 1982.

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