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J Gen Virol 62 (1982), 249-258; DOI 10.1099/0022-1317-62-2-249
© 1982 Society for General Microbiology
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Phospholipids in a Measles Virus Persistent Infection: Modification of Fatty Acid Metabolism and Fatty Acid Composition of Released Virus

P. Anderton, T. F. Wild and G. Zwingelstein

Unité de Virologie Fondamentale et Appliquée, I.N.S.E.R.M. (U.51), Groupe de Recherche C.N.R.S. 33, 1, place Professeur Joseph Renaut, 69371 Lyon Cedex 08, France

The phospholipid metabolism of a measles virus persistently infected cell line, BGM/Hallé, was compared with that of uninfected BGM cells. Synthesis of phospholipid from the isotopic precursor [32P]phosphate was unaffected, but a significant increase in the synthesis of phospholipid from [3H-9,10(n)]palmitic acid was observed in persistently infected cells, reflecting an increase in the palmitic acid content of phospholipid previously described for these cells. The phospholipid composition of measles virus released from persistently infected cells was compared to that of virus from lytically infected BGM cells by radiolabelling to isotopic equilibrium and measuring the incorporation of labelled phosphatides into the virus particle. The incorporation and distribution of [32P]phosphate-labelled phosphatides in virus was similar in lytic and persistent infections. In contrast, the distribution of [3H]palmitic acid among the constituent phosphatides of virus released from the persistent infection was different, partly reflecting the altered saturated fatty acid composition of the phosphatides of the host cell.

Keywords: measles, persistence, phospholipid, fatty acid

Received 11 March 1982; accepted 11 May 1982.




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Copyright © 1982 by the Society for General Microbiology.