HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ito, Y. Articles by Maeno, K. Search for Related Content PubMed PubMed Citation Articles by Ito, Y. Articles by Maeno, K. Agricola Articles by Ito, Y. Articles by Maeno, K.

Interferon Production in Mouse Spleen Cells and Mouse Fibroblasts (L Cells) Stimulated by Various Strains of Newcastle Disease Virus

Yasuhiko Ito^1,

¹ Germfree Life Research Institute
and² Cancer Research Institute Nagoya University School of Medicine, Showa-Ku, Nagoya, Japan

Interferon production in mouse spleen cells and mouse fibroblasts (L cells) stimulated by three strains of Newcastle disease virus (NDV), Italian, La Sota and Ulster, was investigated. Strain Italian was fully infectious and highly virulent; strain Ulster exhibited very low infectivity and very low virulence; strain La Sota was between these extremes. All of these strains of MDBK cell-grown NDV could induce interferon in mouse spleen cells, and it was concluded that proteolytic cleavage of F₀ protein of NDV and, consequently, virus penetration are not necessary for interferon induction in these cells. On the other hand, NDV with uncleaved F₀, which was characterized by an apparent lack of haemolytic and cell fusion activity and infectivity for tissue culture cells, had no interferon-inducing ability in L cells. The cleavage of F₀ protein was paralleled by an appearance of interferon-inducing activity in L cells.

Keywords: NDV-cell interaction, interferon, glycoprotein cleavage

Present address: Department of Measles Virus, National Institute of Health, Musashi-Murayama, Tokyo 190-12, Japan.

Received 16 March 1982; accepted 11 May 1982.

This article has been cited by other articles:

				S. Krishnamurthy, T. Takimoto, R. A. Scroggs, and A. Portner Differentially regulated interferon response determines the outcome of newcastle disease virus infection in normal and tumor cell lines. J. Virol., June 1, 2006; 80(11): 5145 - 5155. [Abstract] [Full Text] [PDF]