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A Mutant Standard Virus Isolated from Vesicular Stomatitis Virus Persistent Infection Interferes Specifically with Wild-type Virus Replication

Katherine R. Spindler

Department of Biology, C-016 University of California, San Diego La Jolla, California 92093, U.S.A.

A clone of vesicular stomatitis virus (VSV) isolated after 76 months of persistence exerts specific homologous interference with replication of wild-type or tsG31 (temperature-sensitive) virus in a mixed infection at 37 °C in the absence of defective-interfering particles. Other VSV ts mutants showed little or no specific interfering ability.

Keywords: interference, nucleocapsids, persistence, mutants

Present address: Department of Microbiology, and Molecular Biology Institute, University of California, Los Angeles, California 90024, U.S.A.

Received 3 March 1982; accepted 25 May 1982.