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Characterization of a Large Genomic Size Moloney Murine Sarcoma Virus Produced by a Transformed Rat Cell Line

INSERM U.248, Unité de Génétique et Expression des Oncogène Faculté de Médecine Lariboisière-St Louis, 10 avenue de Verdun, 75010 Paris, France

A rat cell line (78A1) transformed by the Moloney murine sarcoma virus-Moloney murine leukaemia virus (Mo-MuSV-MuLV) complex was found to produce a sarcoma virus different from the isolates previously described. Analysis of intracellular RNA of the 78A1 cell line by electrophoresis on agarose gel, and hybridization with DNA probes specific to Ml-Mo-MuSV and v-mos^Mo sequences revealed a size of 6.7 kilo-bases (kb) for the RNA of this sarcoma virus. This genome is larger than those of m1, m3, HT1 and 124 isolates and slightly smaller than the myeloproliferative sarcoma virus genome (7.0 kb).

Keywords: Moloney sarcoma virus, retrovirus genome, mRNA

Received 1 February 1982; accepted 8 June 1982.