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Synthesis of a Unique Polypeptide in Measles Virus-infected BGM Cells

Unité de Virologie Fondamentale et Appliquée I.N.S.E.R.M. (U.51), Group de Recherche no. 33 C.N.R.S. 1, Place du Professeur Joseph Renaut, 69371 Lyon Cedex 08, France

In measles virus-infected BGM (African green monkey kidney) cells, a unique polypeptide (84K) was identified. This polypeptide was not found in other cell lines examined and could be immunoprecipitated with anti-NP monoclonal antibody. Peptide mapping studies confirmed that it contained all the peptides of the 60K NP plus several additional ones. Pulse-chase experiments failed to establish it as a precursor of the 60K polypeptide. The possible origin of this protein is discussed.

Keywords: measles, monoclonal antibody, host regulation, virus proteins

Received 18 March 1982; accepted 25 May 1982.

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				R. Sheppard, C. Raine, M. Bornstein, and S. Udem Measles virus matrix protein synthesized in a subacute sclerosing panencephalitis cell line Science, June 7, 1985; 228(4704): 1219 - 1221. [Abstract] [PDF]