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J Gen Virol 63 (1982), 251-254; DOI 10.1099/0022-1317-63-1-251
© 1982 Society for General Microbiology
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Ultraviolet Irradiation of Murine Cytomegalovirus

John D. Shanley{dagger}

Department of Internal Medicine University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, U.S.A.

Ultraviolet irradiation of murine cytomegalovirus (MCMV) caused a rapid dose-related decline in virus infectivity, manifested by virus antigen induction, and in virus production as measured by plaque formation and infectious centre assay. The virus survival curve was multi-component, suggesting host cell-assisted reactivation. Multiplicity reactivation and photoreactivation of MCMV were not observed in these experiments. Productive infection was more sensitive to u.v. irradiation than was virus antigen production, indicating differential inactivation of virus functions. The effects of u.v. irradiation were similar in most respects to those reported for human cytomegalovirus.

Keywords: murine cytomegalovirus, u.v. inactivation, host cell reactivation

{dagger} Present address: Department of Medicine, University of Connecticut Health Center and Newington Veterans Medical Center, Newington, Connecticut 06111, U.S.A.

Received 1 March 1982; accepted 11 June 1982.


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Predicted Inactivation of Viruses of Relevance to Biodefense by Solar Radiation
J. Virol., November 15, 2005; 79(22): 14244 - 14252.
[Abstract] [Full Text] [PDF]


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