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J Gen Virol 63 (1982), 81-94; DOI 10.1099/0022-1317-63-1-81
© 1982 Society for General Microbiology
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Modifications of the Nuclear Envelope of BHK Cells After Infection with Herpes Simplex Virus Type 1

Viviane Bibor-Hardy, Martha Suh, Marcel Pouchelet and René Simard

Institut du Cancer de Montréal, Centre Hospitalier Notre-Dame, 1560 Est, rue Sherbrooke, Montréal, Québec, Canada, H2L 4M1 and Faculté de Médecine, Université de Montréal

Numerous discrete lesions, which we have termed blebs, appeared in the nucleus of BHK cells 10 to 15 h after infection with herpes simplex virus type 1 (HSV-1). They were formed in the inner portion of the nuclear envelope by the apposition of two thickened lamellae overlying a vacuole. As demonstrated by electron microscopic studies, blebs were regular and associated with the peripheral lamina in the nucleus, averaging 3.5 blebs per µm2. They appeared to be associated with an enrichment of the 155K major capsid protein in the nuclear membrane subfractions as compared with the protein composition of nuclei and plasma membrane fractions. We propose that blebs represent the site of assembly of capsid proteins before DNA insertion and eventual envelopment.

Keywords: HSV, nuclear envelope, ultrastructural lesions, protein analysis

Received 8 April 1982; accepted 26 May 1982.


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