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Department of Pathology, University of Cambridge, Cambridge
and1 Department of Medical Microbiology, University of Birmingham, Birmingham, U.K.
The production and properties of three monoclonal antibodies, designated LP1, LP4 and AP2, directed against non-glycosylated polypeptides of herpes simplex virus type 2 are described. LP1 is specific for polypeptide VP16 and cross-reacts with HSV-1; LP4 reacts with the major DNA-binding protein and is type-specific. AP2 is directed against the major capsid antigen of HSV-1 and HSV-2.
Keywords: herpes simplex virus, hybridoma, immunoprecipitation, radioimmune assay
Received 6 April 1982;
accepted 14 July 1982.
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