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J Gen Virol 63 (1982), 441-450; DOI 10.1099/0022-1317-63-2-441
© 1982 Society for General Microbiology
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Secretion of Immunoglobulins by Human Lymphocytes after Infection with Influenza Virus

Madeleine Duc Dodon, Louis Gazzolo, Gérard A. Quash and T. Fabian Wild

Unité de Virologie Fondamentale et Appliquée, I.N.S.E.R.M. (U.51), Groupe de Recherche C.N.R.S. 33, 1 place Professeur Joseph Renaut, 69371 Lyon Cedex 08, France

The biosynthesis of IgM by the Epstein—Barr virus-negative RAMOS lymphoblastoid cell line infected with an influenza A virus, fowl plague virus Dobson strain (FPV-B), was investigated. The results show that FPV infection of RAMOS cells slightly inhibited overall cellular protein synthesis only at 24 h after infection, despite the synthesis of FPV-specific proteins. However, even at this time, the synthesis and secretion of IgM were not affected by virus infection. Secreted IgM contained a reduced amount of sialic acid. The quantity of the asialylated IgM increased proportionally to the amount of enzymically active neuraminidase, suggesting that the asialylation of IgM is due to the action of virus neuraminidase. No such asialylated IgM was observed in RAMOS cells infected with measles virus, which does not possess neuraminidase. These results, together with a previous observation of ours that asialylated immunoglobulins acquire an altered antigenicity, suggest that the modulation of enzyme activities in B lymphocytes in response to an exogenous aggression may lead to disturbances in the structure and in the antigenic properties of immunoglobulins.

Keywords: immunoglobulins, lymphocytes, influenza virus

Received 11 February 1982; accepted 21 June 1982.




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