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Vesicular Stomatitis Virus Can Establish Persistent Infections in Syrian Hamsters

Patricia N. Fultz^1,

¹ Department of Cell Biology
and³ Department of Microbiology University of Texas Health Science Center at Dallas, Dallas, Texas 75235, U.S.A.
and² Department of Veterinary Pathobiology University of Illinois, Urbana-Champaign, Urbana, Illinois 61801, U.S.A.

Persistent infections by vesicular stomatitis virus (VSV) of the Indiana serotype were readily established in adult Syrian hamsters following intraperitoneal injection of the virus. Plaque-forming virus, identified as VSV by serological and physical criteria, was isolated from brain homogenates of five hamsters that were tested 3 to 8 months after infection. Four of these animals had exhibited either transient or permanent paralysis, whereas the fifth appeared healthy, during the period of observation. At the time of sacrifice all hamsters had high titres of anti-VSV-neutralizing antibodies in their sera.

Keywords: vesicular stomatitis virus, persistent infection, pathogenesis

Present address: Department of Biology C-016, University of California, San Diego, La Jolla, California 92093, U.S.A.

Received 22 April 1982; accepted 4 July 1982.

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