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J Gen Virol 63 (1982), 499-503; DOI 10.1099/0022-1317-63-2-499
© 1982 Society for General Microbiology
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Mumps Virus-persistently Infected Cell Cultures Release Defective Interfering Virus Particles

O. G. Andzhaparidze, Yu. S. Boriskin, N. N. Bogomolova and I. D. Drynov

Research Institute for Viral Preparations, Moscow 109088, U.S.S.R.

Two human cell cultures, HEp-2 and L-41, persistently infected with mumps virus, produced small amounts of slowly replicating small-plaque infectious virus and detectable amounts of defective interfering virus particles which were similar to standard mumps virus in polypeptide composition, contained subgenomic size RNAs and interfered with standard mumps virus replication in susceptible cells.

Keywords: mumps virus, persistence, defective virus particles

Received 25 March 1982; accepted 8 July 1982.




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