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Indomethacin and Aspirin Do Not Inhibit the Antiviral or Anti-proliferative Actions of Interferon

¹ Institut de Recherches Scientifiques sur le Cancer Laboratory of Viral Oncology, 94802 Villejuif Cedex, France
² INSERM, Unité 61, 67200 Strasbourg, France

Neither indomethacin nor aspirin, at concentrations which inhibited the formation of prostaglandins and prevented the interferon-induced increase in the intracellular concentration of cyclic GMP, had any significant effect on the development of the interferon-induced antiviral state either in mouse L1210 cells challenged with vesicular stomatitis virus or in mice infected with encephalomyocarditis virus. Furthermore, neither drug had any significant effect on the interferon-induced inhibition of cell multiplication in cultures of mouse leukaemia L1210 cells. The differences in the effects of these cyclo-oxygenase inhibitors on different interferon effects may provide some insight into the different pathways of interferon action.

Keywords: interferon, indomethacin, aspirin

Received 4 June 1982; accepted 13 July 1982.