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A Viable Simian Virus 40 Variant with a Deletion in the Overlapping Genes for Virion Proteins VP1, VP2 and VP3

Michael Piatak^2,

¹ Department of Microbiology University of Massachusetts, Amherst, Massachusetts 01003, U.S.A.
² Department of Human Genetics Yale University School of Medicine, New Haven, Connecticut 06510, U.S.A.

Nucleotide sequence analysis was used to determine the exact location of a deletion in the late region of the SP2 mutant of simian virus 40 (SV40), a viable small-plaque variant isolated from a persistent infection of rhesus monkey kidney cells. The results indicate that six base pairs are deleted from that part of the SV40 genome in which the coding regions for the three virion proteins, VP1, VP2 and VP3, overlap. This implies that all three virion proteins are affected by the deletion. This finding is discussed with respect to the viability of SP2.

Keywords: SV40, deletion mutant, DNA sequence, virion polypeptides

Present address: Cetus, 600 Bancroft Way, Berkeley, California 94710, U.S.A.

Received 27 April 1982; accepted 8 July 1982.