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J Gen Virol 64 (1983), 199-205; DOI 10.1099/0022-1317-64-1-199
© 1983 Society for General Microbiology
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Genetic Studies of Hybrids Between Coliphage {varphi}80 and Salmonella Phage P22

Nobuto Yamamoto1, P. Gemski2 and L. S. Baron2

1 Department of Microbiology and Immunology, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania 19102, U.S.A.
and2 Division of Communicable Disease and Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20012, U.S.A.

Hybrids between Escherichia coli phage {varphi}80 and Salmonella typhimurium phage P22 were isolated after superinfection by P22 of a smooth E. coli-S. typhimurium hybrid lysogenic for {varphi}80. These hybrid phages, designated {varphi}80immP22 and {varphi}80immP22dis, possessed the {varphi}80 protein coat and tail genes. The {varphi}80immP22 hybrids acquired the immunity (immC) region of P22 and some adjacent P22 genes, but E. coli-S. typhimurium strains lysogenic for {varphi}80immP22 hybrids remained sensitive to P22. The {varphi}80immP22dis hybrids, found ten times more frequently than the {varphi}80immP22 hybrids, contained a more extensive portion of the P22 genome which encompassed the immI as well as the immC region of P22. Therefore, the {varphi}80immP22dis hybrids conferred on their hosts immunity to P22 infection. Further analyses have revealed that the {varphi}80immP22dis hybrids carry the P22 attachment region and either P22 tail gene 9 or antigen conversion gene al, but not both of these genes.

Keywords: phage-phage recombination, P22, {varphi}80, genetic homology

Received 21 March 1982; accepted 23 July 1982.




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