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Polyinosinic·Polycytidylic Acid in Association with Cyclic Nucleotides Activates the Antiviral Factor (AVF) in Plant Tissues

The Hebrew University, Faculty of Agriculture, Rehovot, Israel

Leaves and callus cultures from Nicotiana glutinosa L. were treated with a mixture of polyinosinic·policytidylic acid [poly(I)·poly(C)], cyclic AMP and cyclic GMP. A new antiviral activity appearing in the treated tissues co-purified with the antiviral factor AVF. Poly(I)·poly(C) can replace tobacco mosaic virus infection in the induction of AVF activity, the latter being also mediated to a certain extent by cyclic nucleotides. The kinetics of the stimulation of AVF in these in vivo studies suggests that AVF is released by a rapid activation of a pre-existing precursor, thus supporting previous results.

Keywords: AVF, poly(I)·poly(C), cyclic nucleotides, ELISA

Received 7 May 1982; accepted 16 August 1982.