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Altered Expression of Rabies Virus Antigenic Determinants Associated with Chronic Infection and Virulence

B. S. Prabhakar^1,

¹ Department of Microbiology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, U.S.A.
² The Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia Pennsylvania 19104, U.S.A.

Rabies virus may be cultivated in cell culture systems that either enhance the virulence of progeny virus (productive infection of neuroblastoma cells) or lead to attenuation (maintenance in chronically infected cell systems). Our studies using 19 monoclonal antibodies that react with glycoprotein and 19 monoclonal antibodies that react with nucleoprotein have shown that these laboratory-induced changes in the biological properties of rabies virus are accompanied by changes in their antigenic phenotype.

Keywords: rabies, virulence, antigenic determinants, monoclonal antibodies

Present address: National Institutes of Health, Building 30, Room 122, Bethesda, Maryland 20205, U.S.A.

Received 1 April 1982; accepted 8 July 1982.