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Molecular Biological Characterization of a Highly Leukaemogenic Virus Isolated from the Mouse. III. Identity with Mouse Mammary Tumour Virus

¹ Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1
² Frederick Cancer Research Center, Frederick, Maryland 20205, U.S.A.
³ Department of Microbiology and Biochemistry, University of Victoria, Victoria, British Columbia, Canada V8W 2Y2
and⁴ Connaught Laboratories, Toronto, Ontario, Canada

A highly leukaemogenic virus isolate (DMBA-LV) endogenous to the CFW/D mouse has been found to contain two viral genomes. One was closely related to the type B milk-borne mouse mammary tumour virus (MMTV) and present in tenfold excess over a type C viral genome which was only partially related to xenotropic and polytropic isolates from the CFW/D mouse as well as to the ecotropic Moloney murine leukaemia virus isolate. The thymic lymphoma cell line that produced DMBA-LV expressed high levels of MMTV viral RNA (35S and the 24S envelope mRNA). Both the virus and the virus-producing cell line expressed multiple species of type C viral RNA. Similar species of type C viral RNA were also associated with non-infectious, non-leukaemogenic viral particles present in both normal lymphoid cells and in a MMTV-free thymic lymphoma cell line established from a second chemical carcinogen-induced tumour.

Keywords: murine leukaemia virus, MMTV, C-type virus, thymic lymphoma

Received 6 September 1982; accepted 31 May 1983.

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