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P85^gag-mos Encoded by ts110 Moloney Murine Sarcoma Virus: Rapid at the Restrictive Temperature

Department of Tumor Virology, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77030, U.S.A.

The stability of P85^gag-mos, encoded by ts110 Moloney murine sarcoma virus, was studied. P85^gag-mos was found to turn over more rapidly at 39 °C than 33 °C in two different cell lines. One of these is a non-producer cell clone (6m2) which appears only to express P85 at 33 °C. The other cell line (206-2IC) produces P85^gag-mos at both 33 °C and 39 °C, although in lower amounts at the higher temperature. Both cell lines exhibit the normal morphological phenotype following a shift to the restrictive temperature. These data suggest that the presence of P85^gag-mos alone is insufficient to cause transformation, and that some function(s) associated with the molecule may be heat-labile.

Keywords: Mo-MuSV, gag - mos protein, ts, transformation

Received 28 March 1983; accepted 30 June 1983.