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Progressive Invasion of Cell Nuclei by Measles Virus in Persistently Infected Human Cells

Queensland Institute of Medical Research, Bramston Terrace, Herston, Brisbane, Queensland 4006, Australia

The distribution of measles virus antigens in an auto-degenerating persistently infected human cell line (AV₃Al/MV) was examined by a direct fluorescent antibody technique. The appearance of virus antigens in cell nuclei increased with time and passage number, and correlated to a decrease in cell replication rates and increases in cellular pathology and mortality. Nuclei which had been invaded by virus antigens were frequently swollen and the cells tended to have round rather than cuboidal morphologies. The correlation between cell degeneration and viral nuclear invasion in this system suggests that quantification of viral nuclear invasion may be useful as a pathological marker of relative cell morbidity in persistent measles virus infections.

Keywords: measles virus, persistence, nuclear invasion, cell degeneration

Received 18 April 1983; accepted 31 May 1983.